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| Education |
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BSc (Hons) University
of Kent at Canterbury (1991) (wwwbio.ukc.ac.uk)
Biochemistry with studies in Italy
PhD University of Leicester
Biochemistry (1997) (http://www.le.ac.uk/biochem/)
Wellcome Trust U.K.
Travelling Fellow Jan 1999 - Dec 2000
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Sam's Groovy Shoes |
Phil, George and Sam-to-be
Todd and George Butler
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Gus Tester and George Butler: Overall Lab Lunch |
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| Publications |
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Georgina
S. Butler, Eric M. Tam & Christopher M. Overall
J. Biol. Chem. (2004) 10.1074/jbc.M312727200
The Canonical Methionine 392 Of Matrix Metalloproteinase
2 (Gelatinase A) Is Not Required For Catalytic Efficiency Or Structural
Integrity: Probing the Role of the Methionine-turn in the Metzincin
Metalloprotease Superfamily
[Preprint/PDF] |
Kunyan
Zhang, G. Angus McQuibban, Claudia Silva, Georgina S. Butler,
James B. Johnston, Janet Holden, Ian Clark-Lewis, Christopher M.
Overall & Christopher Power
Nature Neurosci. (2003) 6, 1064-1071
HIV-induced Metalloproteinase Cleavage of the Chemokine SDF-1a Causes
Neurodegeneration
[Reprint/PDF]
[HTML] |
Heidi
S.-T. Kai, Georgina S. Butler, Charlotte J. Morrison, Angela
E. King, Gayle R. Pelman, & Christopher M. Overall
J. Biol. Chem. (2002) 277, 48696-48707
Utilization of a Novel Recombinant Myoglobin Fusion Protein Expression
System to Characterize the TIMP-4 and TIMP-2 C-terminal Domain and Tails by Mutagenesis:
The Importance of Acidic Residues in Binding the MMP-2 Hemopexin C Domain
[Reprint
(PDF)] |
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Georgina S. Butler,
Derek Sim, Eric Tam, Dana Devine, & Christopher M. Overall
J.
Biol. Chem. (2002) 277, 17511-17519
Mannose Binding Lectin (MBL) Mutants are Susceptible to Matrix
Metalloproteinase Proteolysis: Potential Role in Human MBL Deficiency
[Reprint (PDF)]
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Charlotte J.
Morrison, Georgina S. Butler, Heather F. Bigg, Clive R.
Roberts, Paul D. Soloway, & Christopher M. Overall
J. Biol.
Chem. (2001) 276, 47402-47410
Cellular Activation of MMP-2 (Gelatinase A) by MT2-MMP
Occurs via a TIMP-2-Independent pathway.
[Reprint
(PDF)] |
McQuibban
G.A., Butler G.S., Gong J.H., Bendall L., Power C., Clark-Lewis
I., & Overall C.M.
J. Biol. Chem. (2001) 276, 43503-43508
Matrix Metalloproteinase activity inactivates the CXC
Chemokine stromal cell-derived factor-1
[Reprint
(PDF)] |
Bigg, H.F.,
Morrison, C.J., Butler, G.S., Bogoyevitch, M.A., Wang,
Z., Soloway. P.D & Overall, C.M.
Cancer Res. (2001) 61, 3610-3618
Tissue Inhibitor of Metalloproteinase-4 Inhibits But Does Not Support
the Activation of Gelatinase A Via Efficient Inhibition of Membrane
Type 1-Matrix Metalloproteinase
[Reprint
(PDF)] |
Butler G.S., Hutton, N.,
Wattam, B.A., Williamson, R.A., Knauper, V., Willenbrock, F. & Murphy,
G.
J. Biol. Chem. (1999) 274, 20391-20396
The Specificity of TIMP-2 for Matrix Metalloproteinases can be Modified
by Single Amino Acid Mutations |
Butler,
G.S.,
Apte, S., Willenbrock, F. & Murphy, G.
J. Biol. Chem.
(1999) 274, 10846-10851
Human Tissue Inhibitor of Metalloproteinases 3 Interacts
with Both the N- and C-terminal Domains of Gelatinases A and B.
Regulation by Polyanions |
Hutton, M., Butler, G.S.,
Wattam, B.A., Willenbrock, F., Williamson, R.A. & Murphy, G.
Ann. N.Y. Acad. Sci. (1999)
878, 524-527
Analysis of the Interaction of TIMP-2 and MMPs: Engineering
the Changes
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Murphy, G.,
Knauper, V., Cowell, S., Hembry, R., Stanton, H., Butler, G.,
Freije, J., Pendas, A. & Lopez-Otin, C.
Ann. N.Y. Acad.
Sci. (1999) 878, 25-39
Evaluation of Some Newer Metalloproteinases |
Murphy, G., Stanton, H., Cowell,
S., Butler, G., Knauper, V., Atkinson, S. & Gavrilovic,
J.
APMIS (1999) 107, 38-44
Mechanisms for Pro-Matrix Metalloproteinase
Activation |
Butler, G.S., Butler,
M.J., Atkinson, S.J., Will, H., Tamura, T., Schade van Westrum,
S., Crabbe, T., Clements, J., d'Ortho, M.P. & Murphy, G.
J.
Biol. Chem. (1998) 273, 871-880
The TIMP2-Membrane-type 1 Metalloproteinase 'Receptor' Regulates
the Concentration and Efficient Activation of Progelatinase A. A Kinetic
study |
d'Ortho, M.-P., Will, H., Atkinson,
S., Butler, G., Messent, A., Gavrilovic, J., Smith, B.,
Timpl, R., Zardi, L. & Murphy, G.
Eur. J. Biochem.
(1997) 250, 751-757
Membrane-type Matrix Metalloproteinases 1 and 2 Exhibit a Broad Spectrum
Proteolytic Capacity Comparable to Many Matrix Metalloproteinases |
Butler, G.S., Will, H.,
Atkinson, S.J. & Murphy, G. (1997)
Eur. J. Biochem. 244, 653-657
Membrane-type-2 matrix metalloproteinase can initiate the processing
of progelatinase A and is regulated by the tissue inhibitors of
metalloproteinases |
Will, H., Atkinson, S.J., Butler,
G.S., Smith, B. & Murphy G.
J. Biol. Chem. (1996) 271, 17119-17123
The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase
Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic
Activation |
Dempsey, C.E. & Butler
G.S.
Biochemistry (1992) 31, 11973-11977
Helical Structure and Orientation of Melittin Dispersed in Phospholipid
Membranes from Amide Exchange Analysis in situ |
Degli Esposti, M., Ghelli, A.,
Butler, G., Roberti, M., Mustich, A. & Cantatore P.
FEBS
(1990) 263, 245-247
The Cytochrome b of the Sea Urchin Paracentrotus Lividus
is Naturally Resistant to Myxothiazol and Mucidin |
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