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Chris Overall
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Biosketch


Invited Seminars 2000-2004


Publications

 
CHRISTOPHER M. OVERALL
Professor
Canada Research Chair
in Metalloproteinase Biology

Department of
Oral Biological & Medical Sciences
Faculty of Dentistry

Associate Member
Department of
Biochemistry & Molecular Biology,
Faculty of Medicine

UBC Centre for Blood Research
CIHR Group in Matrix Dynamics

B.D.S., The University of Adelaide, 1979
B.Sc. (Hons.), The University of Adelaide, 1980
M.D.S., The University of Adelaide, 1985
Ph.D., University of Toronto, 1991

Tel: 1-604-822-2958
Lab: 1-604-822-3561
Fax: 1-604-822-3562
E-mail: chris.overall#ubc.ca
Web: http://www.clip.ubc.ca

Chris Overall at the Nature Horizon Symposia: Signaling Scissors: New Perspectives on Proteases, Palazzo Arzaga, Lake Garda, Italy, October 22-25, 2003


Biography of Chris Overall
Academic Appointments and Positions at the University of British Columbia

M.R.C. Centennial Fellow, Supervisor: Dr Michael Smith, 1989-1992
Assistant Professor, 1992-1994
M.R.C. Clinician Scientist, 1992-1995
Associate Professor, 1994-2000
Associate Member, Department of Biochemistry & Molecular Biology, 1995
M.R.C. Clinician Scientist, Phase 2, 1995-1998
C.I.H.R. Scientist, 2000-2001
Full Professor, 2000
Investigator, CIHR Group in Matrix Dynamics, 2000
Associate Member, UBC Prostate Centre, 2001
Member, UBC Blood Protein Centre, 2002
Canada Research Chair (Tier I) in Metalloproteinase Biology, 2001

"I am Canadian!

Chris wearing favourite Akubra hat, December 2002
Chris Overall "I am Canadian!" December, 2003
Canadian Citizen, 2003

Awards and Distinctions

1. The John Lewis Award and Medal, Royal Geographical Society of Australia (Public Examinations Board, Year 11 geography, first placed student in South Australia), 1972
2. The Australian Dental Association Prize (first placed final year student), 1978
3. Herbert Gill-Williams Scholarship, The University of Adelaide, S.A., 1979
4. J.L. Eustace Memorial Award, The University of Adelaide, S.A., 1983
5. International Association for Dental Research, Australia and N.Z. Division, Travel Award, 1983
6. International Association for Dental Research, Adelaide Sec., Travel Award, 1983
7. J.L. Eustace Scholarship, The University of Adelaide, S.A., 1985-1986
8. Postdoctoral Fellowship, Medical Research Council of Canada, 1984-1989
9. Edward H. Hatton Award, I.A.D.R., First Place Postdoctoral Category, 1987
10. Student Research Award, C.A.D.R., First Place Postdoctoral Category, 1987
11. Young Investigator Award, Third International Conference on the Chemistry and Biology of Mineralised Tissues, 1988
12. American Association for Dental Research, William J. Gies Award ("for the best paper published in the preceding year in the Journal of Dental Research"), 1989
13. Canadian Dental Research Foundation Award, First Place, 1989
14. Young Investigator Award, Matrix Metalloproteinase Conference, 1989
15. The International Association for Dental Research Young Investigator Award (“in recognition of the significant contribution to Dental Research by a junior investigator under the age of 35 years”), 1991
16. Postdoctoral Fellowship, Medical Research Council of Canada (ranked 1st, declined), 1989
17. Centennial Fellowship, Medical Research Council of Canada (ranked 2nd), 1989-1992
18. Scholarship, Medical Research Council of Canada (declined), 1992
19. Clinician Scientist Award, Medical Research Council of Canada, 1992-1995
20. Clinician Scientist Award Phase 2, Medical Research Council of Canada, 1995-1998
21. Medical Research Council Scientist Award (ranked 2nd of 82 applications, Biomedical Research Category), 2000
22. Canada Research Chair (Tier I), 2001
23. 2002 IMHA Canadian Institutes of Health Research Researcher of the Year, 2003


Chris Overall receives the 2002 CIHR IMHA Researcher of the Year Award
2002 CIHR IMHA
Researcher of the Year Award
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Chris Overall in the Clements Lab, British Biotech 1997-1998

Invited Presentations at Conferences (2000-2004)

1. "Complex Role of TIMP-4 in Gelatinase A Activation", " Keynote Speaker ", 2nd Melbourne MMP Mini-Symposium, Melbourne, Victoria, Australia, July 18, 2000.
2. "Chemokine Gradient Inactivation by MMP Activity: Modulation of Tumorigenesis", Invited "International Speaker" , 2000 Hanson Symposium, "Cancer: Biology and Novel Therapeutics" . Adelaide, South Australia 13-16 November 2000.
3. "MMPs are Regulators of Inflammation", Banff Inflammation Workshop 2001 , Banff, Alberta Canada, February 1, 2001.
4. "Degradomics: MMP Modulation of Chemokine Networks", The Third Proteolysis and Biological Control Cold Spring Harbor Meeting , Cold Spring Harbor, NY May 2-6, 2001.
5. "Chemokines: New Substrates of the MMP Degradome", MMP Gordon Research Conference , Il Ciocco, Tuscany, Italy, May 2001.
6. "Complex Role of TIMP-4 in Gelatinase A Activation", Membrane Bound Proteolytic Enzymes and Cancer , Palermo, Italy, May 2001.
7. "Novel Cellular Activation Mechanism of MMP-2 by MT2-MMP", Keio International Symposium: Frontiers in MMP and ADAM Research, Tokyo, Japan, October 2001 (cancelled because of September 11, 2001 events).
8. "CXC Chemokines: New Members of the MMP Degradome", International Proteolysis Society, Second General Meeting , Freising, Germany, November 2001.
9. "MMP Processing of Chemokines", 5 th Symposium of Pan-Pacific Connective Tissue Society , ACT City Hamamatsu, Japan, April 2002 (cancelled because of September 11, 2001 events).
10. "MMPs and the Development of Inflammation", 2002 Gordon Research Conference on the Biology of Spirochetes , Ventura, CA, January 2002.
11. "The Role of MT-MMPs and TIMP-4 in the Cellular Activation of MMP-2", Tumor Invasion Workshop, The Finnish Medical Society, Turku, Finland, September 2002.
12.  "New Roles for MMPs: Chemokine Cleavage, HIV and Dementia" 5 th Duodecim Symposium Matrix Metalloproteinases in Human Pathology , Saariselka, Finland, September 2002.
13. "Processing Functions of MMPs: Chemokine Cleavage Regulates HIV, Inflammatory and Immune Responses", First Meeting of the American Society for Matrix Biology, Houston, Texas, November 2002.
14. " The UBC Mega Project on the Blood Proteome". Pan Canadian Proteomics Meeting, Toronto, November 26-27, 2002.
15.  "Complex Interactions in the Cell Surface Activation of MMP-2", Banff Inflammation Workshop 2003 , Banff, Alberta Canada, February 2, 2003.
16. "The Blood Proteome", Genomics Forum, Genome BC, Vancouver, BC, March 27, 2003
17. "Processing Functions of MMPs: Chemokine Cleavage Regulates Inflammatory Responses and Induces Neuronal Apoptosis in HIV Dementia" VIII th International Symposium on Proteinase Inhibitors and Biological Control, Brdo, Slovenia May 24-28, 2003.
18. "New Roles for MMPs: Chemokine Processing Terminates Inflammation and Initiates Neuronal Apoptosis in HIV Dementia", Plenary speaker at The Fifth Pan Pacific Connective Tissue Meeting, Ube, Yamaguchi, Japan, June 3-7, 2003.
19. "Symbiotic Relationship of MT1-MMP and Cell surface Collagens and TIMP-4", Invited session speaker at The Fifth Pan Pacific Connective Tissue Meeting, Ube, Yamaguchi, Japan, June 3-7, 2003.
20.  "New Roles for MMPs: Chemokine Processing Terminates Inflammation and Initiates Neuronal Apoptosis in HIV Dementia", Invited Symposium Speaker, 6th World Congress on Inflammation, Vancouver, BC Aug. 2-5, 2003.
21. "Searching for Protease Substrates", Invited Symposium Speaker and Moderator, Nature Horizon Symposia: Signaling Scissors: New Perspectives on Proteases , Palazzo Arzaga, Lake Garda, Italy, October 22-25, 2003.
22. "Degradomics: Protease Substrate Discovery by Isotope Coded Affinity Tag Tandem Mass Spectrometry". Invited Program Speaker, 3rd International Meeting of the International Proteolysis Society, Nagoya, Japan, November 10-13, 2003.
23.  "Degradomics: The Human Protease CLIP-CHIP and Protease Substrate Discovery by Isotope Coded Affinity Tag Tandem Mass Spectrometry". Invited Program Speaker, Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference, Ventura CA, February 8-13, 2004.
24. "Degradomics: The Human Protease CLIP-CHIP and Protease Substrate Discovery by Isotope Coded Affinity Tag Tandem Mass Spectrometry". Invited Program Speaker, The Max-Planck Institute for Biochemistry Winter School, Tiers, Italy, February 22-28, 2004.
25. "Degradomics: The Human Protease CLIP-CHIP and Protease Substrate Discovery in Breast carcinoma by Isotope Coded Affinity Tag Tandem Mass Spectrometry". Invited Program Speaker, "Second Chianti Meeting on Proteases: Cross-talk Between Proteinases and the Extracellular Environment", Certosa di Pontignano, Siena, Italy, May 16-20, 2004.
26. " System Wide Analysis of the Human Protease Web: Genomic and Proteomic Approaches ". Invited Program Speaker, Protease Gordon Research Conference, Colby Sawyer, NH, July 5-9, 2004.
27.  " System Wide Analysis of the Human Protease Web: Genomic and Proteomic Approaches ". Invited Program Speaker, Proprotein Processing, Trafficking, and Secretion Gordon Research Conference, Colby Sawyer, NH, July 11-16, 2004.
28. “Degradomics”. Keynote Speaker,VIII International Scleroderma Research Workshop, Trinity College, Cambridge University, Cambridge, UK, July 31-Aug 4, 2004.
29. " MMPS Signal Change ". Invited Program Speaker, Annual Meeting of the Australian Society of Matrix Biology, Perth, Rottnest Island, Western Australia, Sept. 23-26, 2004.
30. " Degradomics: Genomics and Functional Proteomics of Human Proteases ". Plenary Speaker, ComBio 2004, Perth, Western Australia, Sept. 26-30, 2004.
31. “The Protease CLIP-CHIP: The First Dedicated and Complete Human Protease and Inhibitor Oligonucleotide Microarray.” Invited Program Speaker,The Fourth Australasian Microarray Meeting, Freemantle, Western Australia, Oct. 1-2, 2004.
32.“System Wide Analysis of the Human Protease Web: Genomic and Proteomic Approaches”. Invited Keynote Speaker,Eighth International Conference on the Chemistry and Biology of Mineralized Connective Tissues, Banff, AB, October 2004.
33.“Proteomic and Genomic Analysis of MMPI Side Effects.”Invited Program Speaker,Matrix Metalloproteinase Inhibitors (MMPIs): Expanding The Horizon, New York, NY, Oct. 23-25, 2004.
34. “Degradomics: In Search of Substrates and Proteases”. Invited Program Speaker,2005 FASEB Meeting on Proteases in Hemostasis and Vascular Biology, Vermont Academy, Saxtons River, Vermont, July 9-14, 2005.
35. “Degradomics.” Invited Program Speaker,19th Annual Symposium of the Protein Society, Boston, MA, July 30-Aug 3, 2005.
36."New strategies for Identifying Substrates of MMPs, ADAMs and ADAMTSs.”  Invited Program Speaker, 2005 MMP Gordon Research Conference, Big Sky, Montana, August 28-Sept 2, 2005.

Chris Overall with Peter Friedl after the AACR Annual General Meeting, San Francisco, April 2002.  An Amazing meeting...

Chris Overall with Peter Friedl

Chris Overall and Todd Moore, August 2002
Chris Overall with Todd Moore


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MMP, TIMP, MATRIX, METALLO, PROTEINASE, PROTEASE, KINETICS, ASSAYS, TISSUE INHIBITOR, PROTEOMICS, DEGRADOMICS, GELATINASE, MT-MMP, HEMOPEXIN C DOMAIN
EXOSITE, SUBSTRATE, MUTAGENESIS, PROTEIN ENGINEERING, CHEMOKINE, MASS SPECTROMETRY, ICAT, MOLECULAR BIOLOGY, CANCER, CLIP, MMP-1... MMP-2... MMP-3... MMP-7...
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