Chris OVERALL LAB Web Site: MMP+TIMP Degradomics and Proteomics of the Protease Web

www.clip.ubc.ca


	The University of British Columbia Department of Oral Biological & Medical Sciences Department of Biochemistry & Molecular Biology Affiliations CIHR Group in Matrix Dynamics The UBC Centre for Blood Research The UBC Centre for Prostate Research Member of The Canadian Protein Engineering Network Canadian Proteomics Network British Columbian Proteomics Network Canadian Arthritis Network of Centres of Excellence chris overall, overall lab, UBC, Vancouver, BC, Canada	MMP, TIMP, MT-MMP, gelatinase, protease, proteinase, enzyme, marimastat, hemopexin, exosite, domain, chemokine, MCP, SDF collagenase, proteomics, degradomics, CAN, PENCE, gordon, conference, GRC, exosite, metallo, enzyme

A proteomics and protein engineering research laboratory with specialized interest in Degradomics of the Protease Web. We focus on developing new quantitative proteomic techniques to identify and understand the protease degradome (specifically the Matrix Metalloproteinases (MMPs) and their inhibitors, TIMPs, and the deubiquitinylating proteases, DUBs), and their substrates, the substrate degradome, in normal cells and in disease. Therefore we have active research projects in the cancer degradome, in the role of MMPs in controlling the chemokine web and innate immunity, and in HIV infection.